Browse

Latest article

Effects of antibiotics on colonic neurons of the myenteric plexus in wild Peromyscus mice

Gut microbes are essential for the development and functioning of the enteric nervous system. Studies in laboratory mice have observed that antibiotic treatment leads to a reduction in microbial abundance and diversity within the intestine, and these findings are correlated with enteric nervous system structural abnormalities. Specifically, antibiotic-treated mice have an abnormal myenteric plexus, which is characterized by a reduction in myenteric neuron numbers and ganglia area. However, it is unknown whether these effects occur in wild Peromyscus mice that are exposed to a natural bacterial flora. The goal of this study was to evaluate the effects of antibiotic exposure on the colonic neurons of the myenteric plexus in wild Peromyscus mice. Findings suggest that antibiotic-induced microbial dysbiosis affects the colonic neurons and ganglia of wild Peromyscus mice similarly to laboratory mice.

Published volumes

Volume V Issue 2

Winter 2020


Volume V Issue 1

Summer 2020


Volume IV Issue 1

Winter 2019


Volume III Issue 1

Spring 2018


Volume II Issue 2

Summer 2017


Volume II Issue 1

Spring  2017


Volume I Issue 1

Spring 2016

Special editions

AUSxURO Arts Research Award (2021)